4X2U: X-ray crystal structure of the orally available aminopeptidase inhibitor, Tosedostat, bound to the M1 Alanyl Aminopeptidase from P. falciparum

PDB ID: 4X2UDownload
MMDB ID: 127191
PDB Deposition Date: 2014/11/27
Updated in MMDB: 2017/10
Experimental Method:
x-ray diffraction
Resolution: 1.5  Å
Source Organism:
Similar Structures:
Biological Unit for 4X2U: monomeric; determined by author
Molecular Components in 4X2U
Label Count Molecule
Protein (1 molecule)
1
M1 Family Aminopeptidase
Molecule annotation
Chemicals and Non-standard biopolymers (14 molecules)
1
1
ZINC ION (Link to PubChem not yet available)ZINC ION
2
1
(2S)-({(2R)-2-[(1S)-1-hydroxy-2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoyl}amino)(phenyl)ethanoic acid (Link to PubChem not yet available)(2S)-({(2R)-2-[(1S)-1-hydroxy-2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoyl}amino)(phenyl)ethanoic acid
3
4
MAGNESIUM ION (Link to PubChem not yet available)MAGNESIUM ION
4
8
GLYCEROL (Link to PubChem not yet available)GLYCEROL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303