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4X2T:
X-ray crystal structure of the orally available aminopeptidase inhibitor, Tosedostat, bound to the M17 Leucyl Aminopeptidase from P. falciparum
PDB ID:
4X2T
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MMDB ID:
127190
PDB Deposition Date:
2014/11/27
Updated in MMDB:
2023/10
Experimental Method:
x-ray diffraction
Resolution:
2.729 Å
Source Organism:
Plasmodium falciparum 3D7
Similar Structures:
VAST+
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Biological Unit for 4X2T: hexameric; determined by author and by software (PISA)
Molecular Components in 4X2T
Label
Count
Molecule
Proteins (6 molecules)
A
B
C
D
E
F
6
M17 Leucyl Aminopeptidase
Chemicals and Non-standard biopolymers (37 molecules)
1
12
ZINC ION
2
5
(2S)-({(2R)-2-[(1S)-1-hydroxy-2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoyl}amino)(phenyl)ethanoic acid
3
6
CARBONATE ION
4
7
SULFATE ION
5
7
PENTAETHYLENE GLYCOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH.
"
MMDB and VAST+: tracking structural similarities between macromolecular complexes.
Nucleic Acids Res. 2014 Jan; 42(Database issue)
:D297-303