4X2T: X-ray crystal structure of the orally available aminopeptidase inhibitor, Tosedostat, bound to the M17 Leucyl Aminopeptidase from P. falciparum

PDB ID: 4X2TDownload
MMDB ID: 127190
PDB Deposition Date: 2014/11/27
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 2.729  Å
Source Organism:
Similar Structures:
Biological Unit for 4X2T: hexameric; determined by author and by software (PISA)
Molecular Components in 4X2T
Label Count Molecule
Proteins (6 molecules)
6
M17 Leucyl Aminopeptidase
Molecule annotation
Chemicals and Non-standard biopolymers (37 molecules)
1
12
ZINC IONZINC ION
2
5
(2S)-({(2R)-2-[(1S)-1-hydroxy-2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoyl}amino)(phenyl)ethanoic acid(2S)-({(2R)-2-[(1S)-1-hydroxy-2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoyl}amino)(phenyl)ethanoic acid
3
6
CARBONATE IONCARBONATE ION
4
7
SULFATE IONSULFATE ION
5
7
PENTAETHYLENE GLYCOLPENTAETHYLENE GLYCOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303