4X2K: Selection of fragments for kinase inhibitor design: decoration is key

PDB ID: 4X2KDownload
MMDB ID: 126384
PDB Deposition Date: 2014/11/26
Updated in MMDB: 2024/05
Experimental Method:
x-ray diffraction
Resolution: 1.69  Å
Source Organism:
Similar Structures:
Biological Unit for 4X2K: monomeric; determined by software (PISA)
Molecular Components in 4X2K
Label Count Molecule
Protein (1 molecule)
1
Tgf-beta Receptor Type-1
(Gene symbol: TGFBR1)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
1
4-[(3-aminophenyl)amino]pyrido[2,3-d]pyrimidin-5(6H)-one4-[(3-aminophenyl)amino]pyrido[2,3-d]pyrimidin-5(6H)-one
2
1
SULFATE IONSULFATE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303