National Center for
4X1B: Human Serum Transferrin With Ferric Ion Bound At The C-lobe Only
Chem. Commun. (Camb. ) (2015) 51 p.7867-7870
X-ray crystal structures of human serum transferrin (77 kDa) with Yb(III) or Fe(III) bound to the C-lobe and malonate as the synergistic anion show that the large Yb(III) ion causes the expansion of the metal binding pocket while octahedral metal coordination geometry is preserved, an unusual geometry for a lanthanide ion.