4WVF: Crystal structure of KPT276 in complex with CRM1-Ran-RanBP1

PDB ID: 4WVFDownload
MMDB ID: 130911
PDB Deposition Date: 2014/11/5
Updated in MMDB: 2023/12
Experimental Method:
x-ray diffraction
Resolution: 1.8  Å
Source Organism:
Saccharomyces cerevisiae R008▼
Similar Structures:
Biological Unit for 4WVF: trimeric; determined by author and by software (PISA)
Molecular Components in 4WVF
Label Count Molecule
Proteins (3 molecules)
1
Gtp-binding Nuclear Protein RAN
Molecule annotation
1
Ran-specific Gtpase-activating Protein 1
Molecule annotation
1
Crm1p
Molecule annotation
Chemicals and Non-standard biopolymers (12 molecules)
1
1
PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTERPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
2
1
MAGNESIUM IONMAGNESIUM ION
3
2
1,2-ETHANEDIOL1,2-ETHANEDIOL
4
4
GLYCEROLGLYCEROL
5
1
(2E)-3-{3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl}-1-(3,3-difluoroazetidin-1-yl)prop-2-en-1-one(2E)-3-{3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl}-1-(3,3-difluoroazetidin-1-yl)prop-2-en-1-one
6
3
CHLORIDE IONCHLORIDE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303