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4WRS:
Crystal structure of human Pim-1 kinase in complex with an azaspiro pyrazinyl-indazole inhibitor
PDB ID:
4WRS
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MMDB ID:
126756
PDB Deposition Date:
2014/10/25
Updated in MMDB:
2023/12
Experimental Method:
x-ray diffraction
Resolution:
2.2 Å
Source Organism:
Homo sapiens
Similar Structures:
VAST+
Download sequence data
Biological Unit for 4WRS: monomeric; determined by author and by software
Molecular Components in 4WRS
Label
Count
Molecule
Protein (1 molecule)
A
1
Serine/threonine-protein Kinase Pim-1
(Gene symbol:
PIM1
)
Chemicals and Non-standard biopolymers (3 molecules)
1
2
GLYCEROL
2
1
3-{6-[(4R)-6-azaspiro[2.5]oct-4-yloxy]pyrazin-2-yl}-5-(2,6-difluorophenyl)-1H-indazole
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH.
"
MMDB and VAST+: tracking structural similarities between macromolecular complexes.
Nucleic Acids Res. 2014 Jan; 42(Database issue)
:D297-303