4WHZ: Design and Synthesis of Highly Potent and Isoform Selective JNK3 Inhibitors: SAR Studies on Aminopyrazole Derivatives

PDB ID: 4WHZDownload
MMDB ID: 125131
PDB Deposition Date: 2014/9/24
Updated in MMDB: 2023/12
Experimental Method:
x-ray diffraction
Resolution: 1.79  Å
Source Organism:
Similar Structures:
Biological Unit for 4WHZ: monomeric; determined by author and by software (PISA)
Molecular Components in 4WHZ
Label Count Molecule
Protein (1 molecule)
1
Mitogen-activated Protein Kinase 10
(Gene symbol: MAPK10)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
3-(4-{[(2-chlorophenyl)carbamoyl]amino}-1H-pyrazol-1-yl)-N-{1-[(3S)-pyrrolidin-3-yl]-1H-pyrazol-4-yl}benzamide3-(4-{[(2-chlorophenyl)carbamoyl]amino}-1H-pyrazol-1-yl)-N-{1-[(3S)-pyrrolidin-3-yl]-1H-pyrazol-4-yl}benzamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303