4WFU: Bovine Allergen Bos D 2 In The Trigonal Space Group P3221

Citation:
Abstract
Lipocalins are one of the most important groups of inhalant animal allergens. The analysis of structural features of these proteins is important to get insights into their allergenicity. We have determined two different dimeric crystal structures for bovine dander lipocalin Bos d 2, which was earlier described as a monomeric allergen. The crystal structure analysis of all other determined lipocalin allergens also revealed oligomeric structures which broadly utilize inherent structural features of the beta-sheet in dimer formation. According to the moderate size of monomer-monomer interfaces, most of these dimers would be transient in solution. Native mass spectrometry was employed to characterize quantitatively transient dimerization of two lipocalin allergens, Bos d 2 and Bos d 5, in solution.
PDB ID: 4WFUDownload
MMDB ID: 132605
PDB Deposition Date: 2014/9/17
Updated in MMDB: 2015/09
Experimental Method:
x-ray diffraction
Resolution: 1.75  Å
Source Organism:
Similar Structures:
Biological Unit for 4WFU: monomeric; determined by author and by software (PISA)
Molecular Components in 4WFU
Label Count Molecule
Protein (1 molecule)
1
Allergen BOS D 2(Gene symbol: BDA20)
Molecule annotation
* Click molecule labels to explore molecular sequence information.

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