4WEJ: Crystal Structure Of Pseudomonas Aeruginosa Pbp3 With A R4 Substituted Allyl Monocarbam

Citation:
Abstract
A main challenge in the development of new agents for the treatment of Pseudomonas aeruginosa infections is the identification of chemotypes that efficiently penetrate the cell envelope and are not susceptible to established resistance mechanisms. Siderophore-conjugated monocarbams are attractive because of their ability to hijack the bacteria's iron uptake machinery for transport into the periplasm and their inherent stability to metallo-beta-lactamases. Through development of the SAR we identified a number of modifications to the scaffold that afforded active anti-P. aeruginosa agents with good physicochemical properties. Through crystallographic efforts we gained a better understanding into how these compounds bind to the target penicillin binding protein PBP3 and factors to consider for future design.
PDB ID: 4WEJDownload
MMDB ID: 128749
PDB Deposition Date: 2014/9/10
Updated in MMDB: 2015/06
Experimental Method:
x-ray diffraction
Resolution: 2.05  Å
Source Organism:
Similar Structures:
Biological Unit for 4WEJ: monomeric; determined by author
Molecular Components in 4WEJ
Label Count Molecule
Protein (1 molecule)
1
Penicillin-binding Protein 3
Molecule annotation
Chemical (1 molecule)
1
1
* Click molecule labels to explore molecular sequence information.

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