National Center for
4W7Y: Dimeric Bap29 Vded With Disulfide Bonds In Crystal Contacts
Chem. Commun. (Camb. ) (2014) 50 p.14995-14997
The vDED coiled coil domain from human BAP29 was crystallized in dimeric and tetrameric forms. For the dimer, a disulfide bond was unexpectedly found to bridge a crystal contact, resulting in complete cross-linking along the c-axis. This indicates that it is in principle possible to design spontaneously polymerizing protein crystals.