4V25: VER-246608, a novel pan-isoform ATP competitive inhibitor of pyruvate dehydrogenase kinase, disrupts Warburg metabolism and induces context- dependent cytostasis in cancer cells

PDB ID: 4V25Download
MMDB ID: 125287
PDB Deposition Date: 2014/10/6
Updated in MMDB: 2014/12
Experimental Method:
x-ray diffraction
Resolution: 2.6  Å
Source Organism:
Similar Structures:
Biological Unit for 4V25: dimeric; determined by author and by software (PISA)
Molecular Components in 4V25
Label Count Molecule
Proteins (2 molecules)
[pyruvate Dehydrogenase (Acetyl-transferring)] Kinase Isozyme 2, Mitochondrial
(Gene symbol: PDK2)
Molecule annotation
Chemicals and Non-standard biopolymers (6 molecules)
* Click molecule labels to explore molecular sequence information.

Citing MMDB