4UYD: N-terminal Bromodomain Of Human Brd4 With 1,3-dimethyl-2- Oxo-2,3-dihydro-1h-1,3-benzodiazole-5-carboxamide

Citation:
Abstract
The BRPF (bromodomain and PHD finger-containing) protein family are important scaffolding proteins for assembly of MYST histone acetyltransferase complexes. Here, we report the discovery, binding mode, and structure-activity relationship (SAR) of the first potent, selective series of inhibitors of the BRPF1 bromodomain.
PDB ID: 4UYDDownload
MMDB ID: 123300
PDB Deposition Date: 2014/8/30
Updated in MMDB: 2014/12
Experimental Method:
x-ray diffraction
Resolution: 1.37  Å
Source Organism:
Similar Structures:
Biological Unit for 4UYD: monomeric; determined by author and by software (PISA)
Molecular Components in 4UYD
Label Count Molecule
Protein (1 molecule)
1
Bromodomain-containing Protein 4(Gene symbol: BRD4)
Molecule annotation
Chemicals (3 molecules)
1
1
2
1
3
1
* Click molecule labels to explore molecular sequence information.

Citing MMDB
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