4UWK: Discovery Of (2s)-8-((3r)-3-methylmorpholin-4-yl)-1-(3- Methyl-2-oxo-butyl)-2-(trifluoromethyl)-3,4-dihydro-2h- Pyrimido(1,2-a)pyrimidin-6-one: A Novel Potent And Selective Inhibitor Of Vps34 For The Treatment Of Solid Tumors

PDB ID: 4UWKDownload
MMDB ID: 125124
PDB Deposition Date: 2014/8/12
Updated in MMDB: 2014/11
Experimental Method:
x-ray diffraction
Resolution: 2.83  Å
Source Organism:
Similar Structures:
Biological Unit for 4UWK: monomeric; determined by author and by software (PISA)
Molecular Components in 4UWK
Label Count Molecule
Protein (1 molecule)
1
Phosphatidylinositol 3-kinase Catalytic Subunit Type 3
(Gene symbol: PIK3C3)
Molecule annotation
Chemicals and Non-standard biopolymers (3 molecules)
1
1
Sulfate IonSulfate Ion
2
1
GlycerolGlycerol
3
1
(2s)-1-[(5-Chloro-2-Thienyl)methyl]-8-[(3r,5r)-3,5-Dimethylmorpholin-4-Yl]-2-(Trifluoromethyl)-3,4-Dihydro-2h-Pyrimido[1,2-A]pyrimidin-6-One(2s)-1-[(5-Chloro-2-Thienyl)methyl]-8-[(3r,5r)-3,5-Dimethylmorpholin-4-Yl]-2-(Trifluoromethyl)-3,4-Dihydro-2h-Pyrimido[1,2-A]pyrimidin-6-One
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303