4UUH: X-ray crystal structure of human TNKS in complex with a small molecule inhibitor

PDB ID: 4UUHDownload
MMDB ID: 130689
PDB Deposition Date: 2014/7/28
Updated in MMDB: 2015/07
Experimental Method:
x-ray diffraction
Resolution: 2.52  Å
Source Organism:
Similar Structures:
Biological Unit for 4UUH: monomeric; determined by author and by software (PISA)
Molecular Components in 4UUH
Label Count Molecule
Protein (1 molecule)
1
Tankyrase-1
(Gene symbol: TNKS)
Molecule annotation
Chemicals and Non-standard biopolymers (10 molecules)
1
1
ZINC IONZINC ION
2
4
GLYCEROLGLYCEROL
3
4
1,2-ETHANEDIOL1,2-ETHANEDIOL
4
1
5-methyl-3-[4-(piperazin-1-ylmethyl)phenyl]isoquinolin-1(2H)-one5-methyl-3-[4-(piperazin-1-ylmethyl)phenyl]isoquinolin-1(2H)-one
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303