4UMT: Structure Of Melk In Complex With Inhibitors

PDB ID: 4UMTDownload
MMDB ID: 124208
PDB Deposition Date: 2014/5/21
Updated in MMDB: 2014/10
Experimental Method:
x-ray diffraction
Resolution: 1.98  Å
Source Organism:
Similar Structures:
Biological Unit for 4UMT: monomeric; determined by author and by software (PISA)
Molecular Components in 4UMT
Label Count Molecule
Protein (1 molecule)
1
Maternal Embryonic Leucine Zipper Kinase
(Gene symbol: MELK)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
1
Dimethyl SulfoxideDimethyl Sulfoxide
2
1
1-(4-{[3-(Isoquinolin-7-Yl)prop-2-Yn-1-Yl]oxy}-2-Methoxybenzyl)piperazinediium1-(4-{[3-(Isoquinolin-7-Yl)prop-2-Yn-1-Yl]oxy}-2-Methoxybenzyl)piperazinediium
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303