4U93: Crystal Structure of Hsp90-alpha N-domain Bound to the Inhibitor NVP-HSP990

Citation:
Abstract
Utilizing structure-based drug design, a novel dihydropyridopyrimidinone series which exhibited potent Hsp90 inhibition, good pharmacokinetics upon oral administration, and an excellent pharmacokinetic/pharmacodynamic relationship in vivo was developed from a commercial hit. The exploration of this series led to the selection of NVP-HSP990 as a development candidate.
PDB ID: 4U93Download
MMDB ID: 124924
PDB Deposition Date: 2014/8/5
Updated in MMDB: 2017/12
Experimental Method:
x-ray diffraction
Resolution: 1.55  Å
Source Organism:
Similar Structures:
Biological Unit for 4U93: monomeric; determined by author and by software (PISA)
Molecular Components in 4U93
Label Count Molecule
Protein (1 molecule)
1
Heat Shock Protein HSP 90-alpha(Gene symbol: HSP90AA1)
Molecule annotation
Chemical (1 molecule)
1
1
* Click molecule labels to explore molecular sequence information.

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