4U6A: X-ray crystal structure of human TNKS in complex with a small molecule inhibitor

PDB ID: 4U6ADownload
MMDB ID: 130682
PDB Deposition Date: 2014/7/28
Updated in MMDB: 2023/12
Experimental Method:
x-ray diffraction
Resolution: 2.37  Å
Source Organism:
Similar Structures:
Biological Unit for 4U6A: monomeric; determined by author and by software (PISA)
Molecular Components in 4U6A
Label Count Molecule
Protein (1 molecule)
1
Tankyrase-1
(Gene symbol: TNKS)
Molecule annotation
Chemicals and Non-standard biopolymers (9 molecules)
1
1
ZINC IONZINC ION
2
1
3-(4-{[4-(dimethylamino)piperidin-1-yl]methyl}phenyl)-5-methylisoquinolin-1(2H)-one3-(4-{[4-(dimethylamino)piperidin-1-yl]methyl}phenyl)-5-methylisoquinolin-1(2H)-one
3
5
GLYCEROLGLYCEROL
4
2
1,2-ETHANEDIOL1,2-ETHANEDIOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303