4U5M: Structure Of A Left-handed Dna G-quadruplex

Citation:
Abstract
Aside from the well-known double helix, DNA can also adopt an alternative four-stranded structure known as G-quadruplex. Implications of such a structure in cellular processes, as well as its therapeutic and diagnostic applications, have been reported. The G-quadruplex structure is highly polymorphic, but so far, only right-handed helical forms have been observed. Here we present the NMR solution and X-ray crystal structures of a left-handed DNA G-quadruplex. The structure displays unprecedented features that can be exploited as unique recognition elements.
PDB ID: 4U5MDownload
MMDB ID: 127298
PDB Deposition Date: 2014/7/25
Updated in MMDB: 2015/03
Experimental Method:
x-ray diffraction
Resolution: 1.5  Å
Source Organism:
Biological Unit for 4U5M: monomeric; determined by author and by software (PISA)
Molecular Components in 4U5M
Label Count Molecule
Nucleotide(1 molecule)
1
DNA (28-mer)
Molecule annotation
Chemicals (5 molecules)
1
4
2
1
* Click molecule labels to explore molecular sequence information.

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