4U01: HCV NS3/4A serine protease in complex with 6570

PDB ID: 4U01Download
MMDB ID: 131236
PDB Deposition Date: 2014/7/11
Updated in MMDB: 2015/11
Experimental Method:
x-ray diffraction
Resolution: 2.8  Å
Source Organism:
Hepacivirus hominis▼
Similar Structures:
Biological Unit for 4U01: dimeric; determined by author and by software (PISA)
Molecular Components in 4U01
Label Count Molecule
Proteins (2 molecules)
1
Non-structural 3 Protease
Molecule annotation
1
Ns4a Protein
Molecule annotation
Chemicals and Non-standard biopolymers (3 molecules)
1
2
(2S,3aS,10Z,11aS,12aR)-2-({8-fluoro-7-methoxy-2-[4-(propan-2-yl)-1,3-thiazol-2-yl]quinolin-4-yl}oxy)-5-methyl-N-[(1-methylcyclopropyl)sulfonyl]-4,14-dioxo-1,2,3,3a,4,5,6,7,8,9,11a,12,13,14-tetradecahydro-12aH-cyclopropa[m]pyrrolo[1,2-c][1,3,6]triazacyclotetradecine-12a-carboxamide(2S,3aS,10Z,11aS,12aR)-2-({8-fluoro-7-methoxy-2-[4-(propan-2-yl)-1,3-thiazol-2-yl]quinolin-4-yl}oxy)-5-methyl-N-[(1-methylcyclopropyl)sulfonyl]-4,14-dioxo-1,2,3,3a,4,5,6,7,8,9,11a,12,13,14-tetradecahydro-12aH-cyclopropa[m]pyrrolo[1,2-c][1,3,6]triazacyclotetradecine-12a-carboxamide
2
1
ZINC IONZINC ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303