4TZ2: Fragment-Based Screening of the Bromodomain of ATAD2

Citation:
Abstract
Cellular and genetic evidence suggest that inhibition of ATAD2 could be a useful strategy to treat several types of cancer. To discover small-molecule inhibitors of the bromodomain of ATAD2, we used a fragment-based approach. Fragment hits were identified using NMR spectroscopy, and ATAD2 was crystallized with three of the hits identified in the fragment screen.
PDB ID: 4TZ2Download
MMDB ID: 124395
PDB Deposition Date: 2014/7/9
Updated in MMDB: 2017/12
Experimental Method:
x-ray diffraction
Resolution: 1.7  Å
Source Organism:
Similar Structures:
Biological Unit for 4TZ2: monomeric; determined by author and by software (PISA)
Molecular Components in 4TZ2
Label Count Molecule
Protein (1 molecule)
1
Atpase Family AAA Domain-containing Protein 2(Gene symbol: ATAD2)
Molecule annotation
Chemicals (5 molecules)
1
1
2
1
3
2
4
1
* Click molecule labels to explore molecular sequence information.

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