National Center for
4TYL: Fragment-based Screening Of The Bromodomain Of Atad2
J. Med. Chem. (2014) 57 p.9687-9692
Cellular and genetic evidence suggest that inhibition of ATAD2 could be a useful strategy to treat several types of cancer. To discover small-molecule inhibitors of the bromodomain of ATAD2, we used a fragment-based approach. Fragment hits were identified using NMR spectroscopy, and ATAD2 was crystallized with three of the hits identified in the fragment screen.