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4TYD:
Structure-based design of a novel series of azetidine inhibitors of the hepatitis C virus NS3/4A serine protease
PDB ID:
4TYD
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MMDB ID:
123106
PDB Deposition Date:
2014/7/8
Updated in MMDB:
2014/10
Experimental Method:
x-ray diffraction
Resolution:
2.84 Å
Source Organism:
Hepatitis C virus (isolate 1)
Similar Structures:
VAST+
Download sequence data
Biological Unit for 4TYD: trimeric; determined by software
Molecular Components in 4TYD
Label
Count
Molecule
Proteins (3 molecules)
A
D
F
3
NS3 Protease
Chemicals and Non-standard biopolymers (10 molecules)
1
3
ZINC ION
2
3
(4R,6S,7Z,15S,17S)-17-[({7-methoxy-2-[4-(propan-2-yl)-1,3-thiazol-2-yl]quinolin-4-yl}oxy)methyl]-13-methyl-N-[(1-methylcyclopropyl)sulfonyl]-2,14-dioxo-1,3,13-triazatricyclo[13.2.0.0~4,6~]heptadec-7-ene-4-carboxamide
3
4
CHLORIDE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH.
"
MMDB and VAST+: tracking structural similarities between macromolecular complexes.
Nucleic Acids Res. 2014 Jan; 42(Database issue)
:D297-303