4TWP: The crystal structure of human abl1 T315I gatekeeper mutant kinase domain in complex with axitinib

PDB ID: 4TWPDownload
MMDB ID: 126895
PDB Deposition Date: 2014/7/1
Updated in MMDB: 2023/12
Experimental Method:
x-ray diffraction
Resolution: 2.4  Å
Source Organism:
Similar Structures:
Biological Unit for 4TWP: monomeric; determined by author
Molecular Components in 4TWP
Label Count Molecule
Protein (1 molecule)
1
Tyrosine-protein Kinase Abl1
(Gene symbol: ABL1)
Molecule annotation
Chemicals and Non-standard biopolymers (5 molecules)
1
1
AXITINIBAXITINIB
2
2
NICKEL (II) IONNICKEL (II) ION
3
2
SODIUM IONSODIUM ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303