4TTV: Crystal structure of human ThrRS complexing with a bioengineered macrolide BC194

PDB ID: 4TTVDownload
MMDB ID: 133024
PDB Deposition Date: 2014/6/23
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 2.8  Å
Source Organism:
Similar Structures:
Biological Unit for 4TTV: dimeric; determined by author and by software (PISA)
Molecular Components in 4TTV
Label Count Molecule
Proteins (2 molecules)
2
Threonine--trna Ligase, Cytoplasmic
(Gene symbol: TARS1)
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
2
(1R,2R)-2-[(2S,6E,8R,9S,11R,13S,15S,16S)-7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadec-6-en-2-yl]cyclobutanecarboxylic acid(1R,2R)-2-[(2S,6E,8R,9S,11R,13S,15S,16S)-7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadec-6-en-2-yl]cyclobutanecarboxylic acid
2
2
ZINC IONZINC ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303