4TRO: Structure of the enoyl-ACP reductase of Mycobacterium tuberculosis InhA, inhibited with the active metabolite of isoniazid

PDB ID: 4TRODownload
MMDB ID: 240445
PDB Deposition Date: 2014/6/17
Updated in MMDB: 2023/12
Experimental Method:
x-ray diffraction
Resolution: 1.4  Å
Source Organism:
Similar Structures:
Biological Unit for 4TRO: tetrameric; determined by author and by software (PISA)
Molecular Components in 4TRO
Label Count Molecule
Proteins (4 molecules)
4
Enoyl-[acyl-carrier-protein] Reductase [nadh]
Molecule annotation
Chemicals and Non-standard biopolymers (40 molecules)
1
4
NICOTINAMIDE-ADENINE-DINUCLEOTIDENICOTINAMIDE-ADENINE-DINUCLEOTIDE
2
4
ISONICOTINIC-ACETYL-NICOTINAMIDE-ADENINE DINUCLEOTIDEISONICOTINIC-ACETYL-NICOTINAMIDE-ADENINE DINUCLEOTIDE
3
8
4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
4
16
DIMETHYL SULFOXIDEDIMETHYL SULFOXIDE
5
8
SODIUM IONSODIUM ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303