4S0V: Crystal structure of the human OX2 orexin receptor bound to the insomnia drug Suvorexant

PDB ID: 4S0VDownload
MMDB ID: 126081
PDB Deposition Date: 2015/1/6
Updated in MMDB: 2018/11
Experimental Method:
x-ray diffraction
Resolution: 2.5  Å
Source Organism:
Similar Structures:
Biological Unit for 4S0V: monomeric; determined by author and by software (PISA)
Molecular Components in 4S0V
Label Count Molecule
Protein (1 molecule)
1
Human Orexin Receptor Type 2 Fusion Protein to P. Abysii Glycogen Synthase
(Gene symbol: HCRTR2)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
1
[(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone[(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone
2
1
OLEIC ACIDOLEIC ACID
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303