4RZW: Crystal structure of BRAF (R509H) kinase domain bound to AZ628

PDB ID: 4RZWDownload
MMDB ID: 141998
PDB Deposition Date: 2014/12/24
Updated in MMDB: 2023/09
Experimental Method:
x-ray diffraction
Resolution: 3.493  Å
Source Organism:
Similar Structures:
Biological Unit for 4RZW: dimeric; determined by author
Molecular Components in 4RZW
Label Count Molecule
Proteins (2 molecules)
2
Serine/threonine-protein Kinase B-raf
(Gene symbol: BRAF)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
2
3-(2-cyanopropan-2-yl)-N-{4-methyl-3-[(3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]phenyl}benzamide3-(2-cyanopropan-2-yl)-N-{4-methyl-3-[(3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]phenyl}benzamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303