4RYH: Crystal Structure Of Plasmodium Falciparum Dihydroorotate Dehydrogenase Bound With Inhibitor Dsm59

Citation:
Abstract
Plasmodium species are protozoan parasites that are the causative agent of malaria. Malaria is a devastating disease, and its treatment and control have been hampered by the propensity of the parasite to become drug-resistant. Dihydroorotate dehydrogenase (DHODH) has been identified as a promising new target for the development of antimalarial agents. Here, the X-ray structure of P. falciparum DHODH bound to a potent and selective N-phenylbenzamide-based inhibitor (DSM59) is described at 2.3 A resolution. The structure elucidates novel binding-site interactions and shows how conformational flexibility of the enzyme leads to the ability to bind diverse chemical structures with high affinity. This information provides new insight into the design of high-affinity DHODH inhibitors for the treatment of malaria.
PDB ID: 4RYHDownload
MMDB ID: 129225
PDB Deposition Date: 2014/12/15
Updated in MMDB: 2015/05
Experimental Method:
x-ray diffraction
Resolution: 2.3  Å
Source Organism:
Similar Structures:
Biological Unit for 4RYH: monomeric; determined by author and by software (PISA)
Molecular Components in 4RYH
Label Count Molecule
Protein (1 molecule)
1
Dihydroorotate Dehydrogenase (Quinone), Mitochondrial
Molecule annotation
Chemicals (6 molecules)
1
1
2
1
3
1
4
3
* Click molecule labels to explore molecular sequence information.

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