4RX7: SYK Catalytic Domain Complexed with a Potent Triazine Inhibitor

PDB ID: 4RX7Download
MMDB ID: 127885
PDB Deposition Date: 2014/12/9
Updated in MMDB: 2017/12
Experimental Method:
x-ray diffraction
Resolution: 1.8  Å
Source Organism:
Similar Structures:
Biological Unit for 4RX7: monomeric; determined by author and by software (PISA)
Molecular Components in 4RX7
Label Count Molecule
Protein (1 molecule)
1
Tyrosine-protein Kinase SYK
(Gene symbol: SYK)
Molecule annotation
Chemicals and Non-standard biopolymers (3 molecules)
1
1
FORMIC ACIDFORMIC ACID
2
1
GLYCEROLGLYCEROL
3
1
3-{[(1R,2S)-2-aminocyclohexyl]amino}-5-{[3-(2H-1,2,3-triazol-2-yl)phenyl]amino}-1,2,4-triazine-6-carboxamide3-{[(1R,2S)-2-aminocyclohexyl]amino}-5-{[3-(2H-1,2,3-triazol-2-yl)phenyl]amino}-1,2,4-triazine-6-carboxamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303