4RWV: Crystal structure of PIP3 bound human nuclear receptor LRH-1 (Liver Receptor Homolog 1, NR5A2) in complex with a co-regulator DAX-1 (NR0B1) peptide at 1.86 A resolution

PDB ID: 4RWVDownload
MMDB ID: 126322
PDB Deposition Date: 2014/12/5
Updated in MMDB: 2025/12
Experimental Method:
x-ray diffraction
Resolution: 1.859  Å
Source Organism:
Similar Structures:
Biological Unit for 4RWV: dimeric; determined by author and by software (PISA)
Molecular Components in 4RWV
Label Count Molecule
Proteins (2 molecules)
1
Nuclear Receptor Subfamily 5 Group a Member 2
(Gene symbol: NR5A2)
Molecule annotation
1
Nuclear Receptor Dax1
Molecule annotation
Chemicals and Non-standard biopolymers (7 molecules)
1
1
(2S)-3-{[(R)-{[(1S,2S,3R,4S,5S,6S)-2,6-dihydroxy-3,4,5-tris(phosphonooxy)cyclohexyl]oxy}(hydroxy)phosphoryl]oxy}propane -1,2-diyl dihexadecanoate(2S)-3-{[(R)-{[(1S,2S,3R,4S,5S,6S)-2,6-dihydroxy-3,4,5-tris(phosphonooxy)cyclohexyl]oxy}(hydroxy)phosphoryl]oxy}propane -1,2-diyl dihexadecanoate
2
5
1,2-ETHANEDIOL1,2-ETHANEDIOL
3
1
2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303