4RWK: Crystal structure of V561M FGFR1 gatekeeper mutation (C488A, C584S, V561M) in complex with N-{3-[2-(3,5-DIMETHOXYPHENYL)ETHYL]-1H-PYRAZOL-5-YL}-4-[(3R,5S)-3,5-DIMETHYLPIPERAZIN-1-YL]BENZAMIDE (AZD4547)

PDB ID: 4RWKDownload
MMDB ID: 128617
PDB Deposition Date: 2014/12/4
Updated in MMDB: 2017/12
Experimental Method:
x-ray diffraction
Resolution: 2.982  Å
Source Organism:
Similar Structures:
Biological Unit for 4RWK: monomeric; determined by author and by software (PISA)
Molecular Components in 4RWK
Label Count Molecule
Protein (1 molecule)
1
Fibroblast Growth Factor Receptor 1
(Gene symbol: FGFR1)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
1
N-{3-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-5-yl}-4-[(3R,5S)-3,5-dimethylpiperazin-1-yl]benzamideN-{3-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-5-yl}-4-[(3R,5S)-3,5-dimethylpiperazin-1-yl]benzamide
2
1
MAGNESIUM IONMAGNESIUM ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303