4RW9: Crystal Structure of HIV-1 Reverse Transcriptase (Y181C) variant in complex with (E)-3-(3-chloro-5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)phenyl)acrylonitrile (JLJ532), a non-nucleoside inhibitor

PDB ID: 4RW9Download
MMDB ID: 128881
PDB Deposition Date: 2014/12/1
Updated in MMDB: 2017/12
Experimental Method:
x-ray diffraction
Resolution: 2.986  Å
Source Organism:
Similar Structures:
Biological Unit for 4RW9: dimeric; determined by author and by software (PISA)
Molecular Components in 4RW9
Label Count Molecule
Proteins (2 molecules)
1
Reverse Transcriptase/ribonuclease H, P66 Subunit
Molecule annotation
1
Reverse Transcriptase/ribonuclease H, P51 Subunit
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
(2E)-3-(3-chloro-5-{2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]phenoxy}phenyl)prop-2-enenitrile(2E)-3-(3-chloro-5-{2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]phenoxy}phenyl)prop-2-enenitrile
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303