4RSZ: The X-ray Structure Of The Primary Adduct Formed In The Reaction Between Cisplatin And Cytochrome C

Citation:
Abstract
In the present study, the interactions between cisplatin and cytochrome c are investigated. Based on high-resolution X-ray diffraction data, two monometalated species, i.e. cyt c-Pt(NH3)2 and cyt c-Pt(NH3)2Cl, are found to be the main adducts that form in the reaction between the protein and the drug. Both monodentate and bidentate platinum coordination to the protein is observed, with platinum binding either to Met65 or to Met65 and Glu61, simultaneously.
PDB ID: 4RSZDownload
MMDB ID: 126075
PDB Deposition Date: 2014/11/12
Updated in MMDB: 2015/02
Experimental Method:
x-ray diffraction
Resolution: 2.19  Å
Source Organism:
Similar Structures:
Biological Unit for 4RSZ: monomeric; determined by author
Molecular Components in 4RSZ
Label Count Molecule
Protein (1 molecule)
1
Cytochrome C(Gene symbol: CYCS)
Molecule annotation
Chemicals (8 molecules)
1
2
2
1
3
4
4
1
* Click molecule labels to explore molecular sequence information.

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