4RIO: Crystal structure of JAK3 kinase domain in complex with a pyrrolopyridazine carboxamide inhibitor

PDB ID: 4RIODownload
MMDB ID: 150282
PDB Deposition Date: 2014/10/7
Updated in MMDB: 2017/05
Experimental Method:
x-ray diffraction
Resolution: 2.69  Å
Source Organism:
Similar Structures:
Biological Unit for 4RIO: monomeric; determined by author and by software (PISA)
Molecular Components in 4RIO
Label Count Molecule
Protein (1 molecule)
1
Tyrosine-protein Kinase Jak3
(Gene symbol: JAK3)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
4-{[(1R,2S)-2-fluoro-2-methylcyclopentyl]amino}pyrrolo[1,2-b]pyridazine-3-carboxamide4-{[(1R,2S)-2-fluoro-2-methylcyclopentyl]amino}pyrrolo[1,2-b]pyridazine-3-carboxamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303