National Center for
4RH1: Spore Photoproduct Lyase C140a/s76c Mutant With Bound Adomet And Dinucleoside Spore Photoproduct
Rescuing DNA repair activity by rewiring the H-atom transfer pathway in the radical SAM enzyme, spore photoproduct lyase
Chem. Commun. (Camb. ) (2014) 50 p.14201-14204
The radical SAM enzyme, spore photoproduct lyase, requires an H-atom transfer (HAT) pathway to catalyze DNA repair. By rational engineering, we demonstrate that it is possible to rewire its HAT pathway, a first step toward the development of novel catalysts based on the radical SAM enzyme scaffold.