4RFM: Itk Kinase Domain In Complex With Compound 1 N-{1-[(1,1-dioxo-1-thian- 2-yl)(phenyl)methyl]-1h- Pyrazol-4-yl}-5,5-difluoro-5a-methyl-1h,4h, 4ah,5h,5ah,6h-cyclopropa[f]indazole-3-carboxamide

PDB ID: 4RFMDownload
MMDB ID: 128875
PDB Deposition Date: 2014/9/26
Updated in MMDB: 2015/08
Experimental Method:
x-ray diffraction
Resolution: 2.1  Å
Source Organism:
Similar Structures:
Biological Unit for 4RFM: monomeric; determined by author and by software (PISA)
Molecular Components in 4RFM
Label Count Molecule
Protein (1 molecule)
1
Tyrosine-protein Kinase Itk/tsk
(Gene symbol: ITK)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
(4as,5ar)-N-{1-[(R)-[(2r)-1,1-Dioxidotetrahydro-2h-Thiopyran-2-Yl](Phenyl)methyl]-1h-Pyrazol-4-Yl}-5,5-Difluoro-5a-Methyl-1,4,4a,5,5a,6-Hexahydrocyclopropa[f]indazole-3-Carboxamide(4as,5ar)-N-{1-[(R)-[(2r)-1,1-Dioxidotetrahydro-2h-Thiopyran-2-Yl](Phenyl)methyl]-1h-Pyrazol-4-Yl}-5,5-Difluoro-5a-Methyl-1,4,4a,5,5a,6-Hexahydrocyclopropa[f]indazole-3-Carboxamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303