4RAB: Aza-acyclic Nucleoside Phosphonates Containing A Second Phosphonate Group As Inhibitors Of The Human, Plasmodium Falciparum And Vivax 6- Oxopurine Phosphoribosyltransferases And Their Pro-drugs As Antimalarial Agents

PDB ID: 4RABDownload
MMDB ID: 125918
PDB Deposition Date: 2014/9/10
Updated in MMDB: 2015/12
Experimental Method:
x-ray diffraction
Resolution: 2.26  Å
Source Organism:
Similar Structures:
Biological Unit for 4RAB: tetrameric; determined by author and by software (PISA)
Molecular Components in 4RAB
Label Count Molecule
Proteins (4 molecules)
4
Hypoxanthine-guanine Phosphoribosyltransferase
(Gene symbol: HPRT1)
Molecule annotation
Chemicals and Non-standard biopolymers (14 molecules)
1
4
[(E)-2-(2-{[2-(2-Amino-8-Bromo-6-Oxo-1,6-Dihydro-9h-Purin-9-Yl)ethyl][(E)-2-Phosphonoethenyl]amino}ethoxy)ethenyl]phosphonic Acid[(E)-2-(2-{[2-(2-Amino-8-Bromo-6-Oxo-1,6-Dihydro-9h-Purin-9-Yl)ethyl][(E)-2-Phosphonoethenyl]amino}ethoxy)ethenyl]phosphonic Acid
2
6
Magnesium IonMagnesium Ion
3
4
Phosphate IonPhosphate Ion
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303