4R6V: Crystal Structure Of Fgf Receptor (fgfr) 4 Kinase Harboring The V550l Gate-keeper Mutation In Complex With Fiin-3, An Irreversible Tyrosine Kinase Inhibitor Capable Of Overcoming Fgfr Kinase Gate-keeper Mutations

PDB ID: 4R6VDownload
MMDB ID: 124370
PDB Deposition Date: 2014/8/26
Updated in MMDB: 2014/11
Experimental Method:
x-ray diffraction
Resolution: 2.35  Å
Source Organism:
Similar Structures:
Biological Unit for 4R6V: monomeric; determined by author and by software (PISA)
Molecular Components in 4R6V
Label Count Molecule
Protein (1 molecule)
1
Fibroblast Growth Factor Receptor 4
(Gene symbol: FGFR4)
Molecule annotation
Chemicals and Non-standard biopolymers (3 molecules)
1
1
N-[4-({[(2,6-Dichloro-3,5-Dimethoxyphenyl)carbamoyl](6-{[4-(4-Methylpiperazin-1-Yl)phenyl]amino}pyrimidin-4-Yl)amino}methyl)phenyl]propanamideN-[4-({[(2,6-Dichloro-3,5-Dimethoxyphenyl)carbamoyl](6-{[4-(4-Methylpiperazin-1-Yl)phenyl]amino}pyrimidin-4-Yl)amino}methyl)phenyl]propanamide
2
2
Sulfate IonSulfate Ion
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303