4R5P: Crystal structure of HIV-1 reverse transcriptase (RT) with DNA and a nucleoside triphosphate mimic alpha-carboxy nucleoside phosphonate inhibitor

PDB ID: 4R5PDownload
MMDB ID: 127657
PDB Deposition Date: 2014/8/21
Updated in MMDB: 2023/09
Experimental Method:
x-ray diffraction
Resolution: 2.894  Å
Source Organism:
synthetic construct▼
Similar Structures:
Biological Unit for 4R5P: tetrameric; determined by author and by software (PISA)
Molecular Components in 4R5P
Label Count Molecule
Proteins (2 molecules)
1
Hiv-1 Reverse Transcriptase, P66 Subunit
Molecule annotation
1
Hiv-1 Reverse Transcriptase, P51 Subunit
Molecule annotation
Nucleotides(2 molecules)
1
5'-d(*tp*gp*gp*ap*cp*gp*gp*cp*gp*cp*cp*cp*gp*ap*ap*cp*ap*gp*gp*gp*ap*cp*tp*g)-3'
Molecule annotation
1
5'-d(*cp*ap*gp*tp*cp*cp*cp*tp*gp*tp*tp*cp*gp*gp*(mrg)p*cp*gp*cp*cp*g)-3'
Molecule annotation
Chemicals and Non-standard biopolymers (9 molecules)
1
2
alpha-D-glucopyranose (Link to PubChem not yet available)alpha-D-glucopyranose
2
1
beta-D-fructofuranose (Link to PubChem not yet available)beta-D-fructofuranose
3
4
MAGNESIUM ION (Link to PubChem not yet available)MAGNESIUM ION
4
2
[(1R)-2-methoxy-1-{[(1S,3R)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)cyclopentyl]oxy}-2-oxoethyl]phosphonic acid (Link to PubChem not yet available)[(1R)-2-methoxy-1-{[(1S,3R)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)cyclopentyl]oxy}-2-oxoethyl]phosphonic acid
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303