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4R5N:
8-tetrahydropyran-2-yl Chromans: Highly Selective Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (bace1) Inhibitors
PDB ID:
4R5N
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MMDB ID:
125231
PDB Deposition Date:
2014/8/21
Updated in MMDB:
2014/12
Experimental Method:
x-ray diffraction
Resolution:
1.8 Å
Source Organism:
Homo sapiens
Similar Structures:
VAST+
Download sequence data
Biological Unit for 4R5N: monomeric; determined by author and by software (PISA)
Molecular Components in 4R5N
Label
Count
Molecule
Protein (1 molecule)
A
1
Beta-secretase 1
(Gene symbol:
BACE1
)
Chemicals and Non-standard biopolymers (2 molecules)
1
1
Nickel (Ii) Ion
2
1
(4r,4a's,10a'r)-8'-(2-Fluoropyridin-3-Yl)-4a'-Methyl-3',4',4a',10a'-Tetrahydro-2'h-Spiro[1,3-Oxazole-4,10'-Pyrano[3,2-B]chromen]-2-Amine
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH.
"
MMDB and VAST+: tracking structural similarities between macromolecular complexes.
Nucleic Acids Res. 2014 Jan; 42(Database issue)
:D297-303