4R47: Racemic Crystal Structure Of A Bimolecular Dna G-quadruplex (p21/n)

Citation:
Angew. Chem. Int. Ed. Engl. (2014) 53 p.14424-14427
Abstract
Racemates increase the chances of crystallization by allowing molecular contacts to be formed in a greater number of ways. With the advent of protein synthesis, the production of protein racemates and racemic-protein crystallography are now possible. Curiously, racemic DNA crystallography had not been investigated despite the commercial availability of L- and D-deoxyribo-oligonucleotides. Here, we report a study into racemic DNA crystallography showing the strong propensity of racemic DNA mixtures to form racemic crystals. We describe racemic crystal structures of various DNA sequences and folded conformations, including duplexes, quadruplexes, and a four-way junction, showing that the advantages of racemic crystallography should extend to DNA.
PDB ID: 4R47Download
MMDB ID: 124689
PDB Deposition Date: 2014/8/19
Updated in MMDB: 2014/11
Experimental Method:
x-ray diffraction
Resolution: 1.85  Å
Source Organism:
Biological Unit for 4R47: dimeric; determined by author
Molecular Components in 4R47
Label Count Molecule
Nucleotide(1 molecule)
2
5'-d(*gp*gp*gp*gp*tp*tp*tp*tp*gp*gp*gp*g)-3'
Molecule annotation
Chemicals (8 molecules)
1
5
2
3
* Click molecule labels to explore molecular sequence information.

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