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4R1V:
Identification and optimization of pyridazinones as potent and selective c-Met kinase inhibitors
PDB ID:
4R1V
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MMDB ID:
127874
PDB Deposition Date:
2014/8/7
Updated in MMDB:
2015/04
Experimental Method:
x-ray diffraction
Resolution:
1.2 Å
Source Organism:
Homo sapiens
Similar Structures:
VAST+
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Biological Unit for 4R1V: monomeric; determined by author and by software (PISA)
Molecular Components in 4R1V
Label
Count
Molecule
Protein (1 molecule)
A
1
Hepatocyte Growth Factor Receptor
(Gene symbol:
MET
)
Chemicals and Non-standard biopolymers (4 molecules)
1
1
3-[1-(3-{5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl}benzyl)-6-oxo-1,6-dihydropyridazin-3-yl]benzonitrile
2
3
GAMMA-BUTYROLACTONE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH.
"
MMDB and VAST+: tracking structural similarities between macromolecular complexes.
Nucleic Acids Res. 2014 Jan; 42(Database issue)
:D297-303