4R09: Crystal Structure Of Human Tlr8 In Complex With Orn06s

PDB ID: 4R09Download
MMDB ID: 126057
PDB Deposition Date: 2014/7/30
Updated in MMDB: 2015/02
Experimental Method:
x-ray diffraction
Resolution: 2.62  Å
Source Organism:
Similar Structures:
Biological Unit for 4R09: dimeric; determined by author and by software (PISA)
Molecular Components in 4R09
Label Count Molecule
Proteins (2 molecules)
2
Toll-like Receptor 8
(Gene symbol: TLR8)
Molecule annotation
Chemicals and Non-standard biopolymers (21 molecules)
1
2
UridineUridine
2
2
O-[(2r,3s,4r,5r)-5-(2-Amino-6-Oxo-3,6-Dihydro-9h-Purin-9-Yl)-2-({[(S)-({(2r,3s,4r,5r)-5-(2,4-Dioxo-3,4-Dihydropyrimidin-1(2h)-Yl)-4-Hydroxy-2-[(Thiophosphonooxy)methyl]tetrahydrofuran-3-Yl}oxy)(Sulfanyl)phosphoryl]oxy}methyl)-4-Hydroxytetrahydrofuran-3-Yl] Dihydrogen (S)-PhosphorothioateO-[(2r,3s,4r,5r)-5-(2-Amino-6-Oxo-3,6-Dihydro-9h-Purin-9-Yl)-2-({[(S)-({(2r,3s,4r,5r)-5-(2,4-Dioxo-3,4-Dihydropyrimidin-1(2h)-Yl)-4-Hydroxy-2-[(Thiophosphonooxy)methyl]tetrahydrofuran-3-Yl}oxy)(Sulfanyl)phosphoryl]oxy}methyl)-4-Hydroxytetrahydrofuran-3-Yl] Dihydrogen (S)-Phosphorothioate
3
2
1-[(2r,3ar,4r,6r,6ar)-2-Hydroxy-6-(Hydroxymethyl)-2-Sulfidotetrahydrofuro[3,4-D][1,3,2]dioxaphosphol-4-Yl]pyrimidine-2,4(1h,3h)-Dione1-[(2r,3ar,4r,6r,6ar)-2-Hydroxy-6-(Hydroxymethyl)-2-Sulfidotetrahydrofuro[3,4-D][1,3,2]dioxaphosphol-4-Yl]pyrimidine-2,4(1h,3h)-Dione
4
12
N-Acetyl-D-GlucosamineN-Acetyl-D-Glucosamine
5
2
Beta-D-MannoseBeta-D-Mannose
6
1
Alpha-D-MannoseAlpha-D-Mannose
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303