National Center for
4QY3: The Crystal Structure Of The Complex Of Hcaii With An Ortho- Substituted Benzoic Acid
Chem. Commun. (Camb. ) (2014) 51 p.302-305
A structural study of the adduct which 2-benzylsulfinylbenzoic acid forms with human carbonic anhydrase II is reported, showing a binding mode completely different from any other class of carbonic anhydrase inhibitors investigated so far; this carboxylate binds in a pocket situated out of the enzyme active site.