4QX4: Human Aldose Reductase complexed with a ligand with a new scaffold at 1.26 A

PDB ID: 4QX4Download
MMDB ID: 128222
PDB Deposition Date: 2014/7/18
Updated in MMDB: 2023/09
Experimental Method:
x-ray diffraction
Resolution: 1.259  Å
Source Organism:
Similar Structures:
Biological Unit for 4QX4: monomeric; determined by author and by software (PISA)
Molecular Components in 4QX4
Label Count Molecule
Protein (1 molecule)
1
Aldose Reductase
(Gene symbol: AKR1B1)
Molecule annotation
Chemicals and Non-standard biopolymers (3 molecules)
1
1
NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE (Link to PubChem not yet available)NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
2
2
(3-thioxo-2,3-dihydro-5H-[1,2,4]triazino[5,6-b]indol-5-yl)acetic acid (Link to PubChem not yet available)(3-thioxo-2,3-dihydro-5H-[1,2,4]triazino[5,6-b]indol-5-yl)acetic acid
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303