National Center for
Biotechnology Information

4QW5: yCP beta5-M45A mutant in complex with carfilzomib

PDB ID:	4QW5 Download
MMDB ID:	126675
PDB Deposition Date:	2014/7/16
Updated in MMDB:	2022/11
Experimental Method:	x-ray diffraction
Resolution:	3 Å
Source Organism:	Saccharomyces cerevisiae S288C
Similar Structures:

Biological Unit for 4QW5: 28-meric; determined by author

Molecular Components in 4QW5
Label	Count	Molecule
Proteins (28 molecules)
A O	2	Proteasome Subunit Alpha Type-2 (Gene symbol: PRE8)
B P	2	Proteasome Subunit Alpha Type-3 (Gene symbol: PRE9)
C Q	2	Proteasome Subunit Alpha Type-4 (Gene symbol: PRE6)
D R	2	Proteasome Subunit Alpha Type-5 (Gene symbol: PUP2)
E S	2	Proteasome Subunit Alpha Type-6 (Gene symbol: PRE5)
F T	2	Probable Proteasome Subunit Alpha Type-7 (Gene symbol: PRE10)
G U	2	Proteasome Subunit Alpha Type-1 (Gene symbol: SCL1)
H V	2	Proteasome Subunit Beta Type-2 (Gene symbol: PUP1)
I W	2	Proteasome Subunit Beta Type-3 (Gene symbol: PUP3)
J X	2	Proteasome Subunit Beta Type-4 (Gene symbol: PRE1)
K Y	2	Proteasome Subunit Beta Type-5 (Gene symbol: PRE2)
L Z	2	Proteasome Subunit Beta Type-6 (Gene symbol: PRE7)
M a	2	Proteasome Subunit Beta Type-7 (Gene symbol: PRE4)
N b	2	Proteasome Subunit Beta Type-1 (Gene symbol: PRE3)
Chemicals and Non-standard biopolymers (19 molecules)
1	5	MAGNESIUM ION (Link to PubChem not yet available)
2	4	CHLORIDE ION (Link to PubChem not yet available)
3	6	N-{(2S)-2-[(morpholin-4-ylacetyl)amino]-4-phenylbutanoyl}-L-leucyl-N-[(2R,3S,4S)-1,3-dihydroxy-2,6-dimethylheptan-4-yl]-L-phenylalaninamide (Link to PubChem not yet available)
4	4	2-(N-MORPHOLINO)-ETHANESULFONIC ACID (Link to PubChem not yet available)

* Click molecule labels to explore molecular sequence information.

Citing MMDB