4QQC: Crystal Structure of FGF Receptor (FGFR) 4 Kinase Domain in Complex with FIIN-2, an Irreversible Tyrosine Kinase Inhibitor Capable of Overcoming FGFR Kinase Gate-Keeper Mutations

PDB ID: 4QQCDownload
MMDB ID: 124356
PDB Deposition Date: 2014/6/27
Updated in MMDB: 2014/11
Experimental Method:
x-ray diffraction
Resolution: 2.4  Å
Source Organism:
Similar Structures:
Biological Unit for 4QQC: monomeric; determined by author and by software (PISA)
Molecular Components in 4QQC
Label Count Molecule
Protein (1 molecule)
Fibroblast Growth Factor Receptor 4
(Gene symbol: FGFR4)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
N-(4-{[3-(3,5-dimethoxyphenyl)-7-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl]methyl}phenyl)propanamide (Link to PubChem not yet available)N-(4-{[3-(3,5-dimethoxyphenyl)-7-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl]methyl}phenyl)propanamide
SULFATE ION (Link to PubChem not yet available)SULFATE ION
* Click molecule labels to explore molecular sequence information.

Citing MMDB