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4QQC:
Crystal Structure Of Fgf Receptor (fgfr) 4 Kinase Domain In Complex With Fiin-2, An Irreversible Tyrosine Kinase Inhibitor Capable Of Overcoming Fgfr Kinase Gate-keeper Mutations
PDB ID:
4QQC
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MMDB ID:
124356
PDB Deposition Date:
2014/6/27
Updated in MMDB:
2014/11
Experimental Method:
x-ray diffraction
Resolution:
2.4 Å
Source Organism:
Homo sapiens
Similar Structures:
VAST+
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Biological Unit for 4QQC: monomeric; determined by author and by software (PISA)
Molecular Components in 4QQC
Label
Count
Molecule
Protein (1 molecule)
A
1
Fibroblast Growth Factor Receptor 4
(Gene symbol:
FGFR4
)
Chemicals and Non-standard biopolymers (2 molecules)
1
1
N-(4-{[3-(3,5-Dimethoxyphenyl)-7-{[4-(4-Methylpiperazin-1-Yl)phenyl]amino}-2-Oxo-3,4-Dihydropyrimido[4,5-D]pyrimidin-1(2h)-Yl]methyl}phenyl)propanamide
2
1
Sulfate Ion
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH.
"
MMDB and VAST+: tracking structural similarities between macromolecular complexes.
Nucleic Acids Res. 2014 Jan; 42(Database issue)
:D297-303