4QQC: Crystal Structure Of Fgf Receptor (fgfr) 4 Kinase Domain In Complex With Fiin-2, An Irreversible Tyrosine Kinase Inhibitor Capable Of Overcoming Fgfr Kinase Gate-keeper Mutations

PDB ID: 4QQCDownload
MMDB ID: 124356
PDB Deposition Date: 2014/6/27
Updated in MMDB: 2014/11
Experimental Method:
x-ray diffraction
Resolution: 2.4  Å
Source Organism:
Similar Structures:
Biological Unit for 4QQC: monomeric; determined by author and by software (PISA)
Molecular Components in 4QQC
Label Count Molecule
Protein (1 molecule)
1
Fibroblast Growth Factor Receptor 4
(Gene symbol: FGFR4)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
1
N-(4-{[3-(3,5-Dimethoxyphenyl)-7-{[4-(4-Methylpiperazin-1-Yl)phenyl]amino}-2-Oxo-3,4-Dihydropyrimido[4,5-D]pyrimidin-1(2h)-Yl]methyl}phenyl)propanamideN-(4-{[3-(3,5-Dimethoxyphenyl)-7-{[4-(4-Methylpiperazin-1-Yl)phenyl]amino}-2-Oxo-3,4-Dihydropyrimido[4,5-D]pyrimidin-1(2h)-Yl]methyl}phenyl)propanamide
2
1
Sulfate IonSulfate Ion
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303