4PS8: Structure Of Pi3k Gamma In Complex With N-[6-(5,6-dimethoxypyridin-3- Yl)-1,3-benzothiazol-2-yl]acetamide

Citation:
Abstract
Phosphoinositide 3-kinase gamma (PI3Kgamma) is an attractive target to potentially treat a range of disease states. Herein, we describe the evolution of a reported phenylthiazole pan-PI3K inhibitor into a family of potent and selective benzothiazole inhibitors. Using X-ray crystallography, we discovered that compound 22 occupies a previously unreported hydrophobic binding cleft adjacent to the ATP binding site of PI3Kgamma, and achieves its selectivity by exploiting natural sequence differences among PI3K isoforms in this region.
PDB ID: 4PS8Download
MMDB ID: 119484
PDB Deposition Date: 2014/3/6
Updated in MMDB: 2014/05
Experimental Method:
x-ray diffraction
Resolution: 2.99  Å
Source Organism:
Similar Structures:
Biological Unit for 4PS8: monomeric; determined by author and by software (PISA)
Molecular Components in 4PS8
Label Count Molecule
Protein (1 molecule)
1
Phosphatidylinositol 4,5-bisphosphate 3-kinase Catalytic Subunit Gamma Isoform(Gene symbol: PIK3CG)
Molecule annotation
Chemical (1 molecule)
1
1
* Click molecule labels to explore molecular sequence information.

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