4PGZ: Structural basis of KIT activation by oncogenic mutations in the extracellular region reveals a zipper-like mechanism for ligand-dependent or oncogenic receptor tyrosine kinase activation

PDB ID: 4PGZDownload
MMDB ID: 127842
PDB Deposition Date: 2014/5/3
Updated in MMDB: 2023/12
Experimental Method:
x-ray diffraction
Resolution: 2.4  Å
Source Organism:
Similar Structures:
Biological Unit for 4PGZ: dimeric; determined by author and by software (PISA)
Molecular Components in 4PGZ
Label Count Molecule
Proteins (2 molecules)
2
Mast/stem Cell Growth Factor Receptor KIT
(Gene symbol: KIT)
Molecule annotation
Chemicals and Non-standard biopolymers (6 molecules)
1
2
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
2
4
COBALT (II) IONCOBALT (II) ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303