4P4E: X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with a phosphoramidate inhibitor MP1D

PDB ID: 4P4EDownload
MMDB ID: 129405
PDB Deposition Date: 2014/3/12
Updated in MMDB: 2024/12
Experimental Method:
x-ray diffraction
Resolution: 1.67  Å
Source Organism:
Similar Structures:
Biological Unit for 4P4E: dimeric; determined by author and by software (PISA)
Molecular Components in 4P4E
Label Count Molecule
Proteins (2 molecules)
2
Glutamate Carboxypeptidase 2
(Gene symbol: FOLH1)
Molecule annotation
Chemicals and Non-standard biopolymers (38 molecules)
1
21
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
2
4
alpha-L-fucopyranosealpha-L-fucopyranose
3
3
beta-D-mannopyranosebeta-D-mannopyranose
4
4
ZINC IONZINC ION
5
2
CALCIUM IONCALCIUM ION
6
2
CHLORIDE IONCHLORIDE ION
7
2
N-[(S)-hydroxy(4-phenylbutoxy)phosphoryl]-L-glutamic acidN-[(S)-hydroxy(4-phenylbutoxy)phosphoryl]-L-glutamic acid
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303